DB00464 - Sodium Tetradecyl Sulfate
| Identification | |
|---|---|
| Name | Sodium Tetradecyl Sulfate |
| Accession Number | DB00464 (APRD00575) |
| Type | small molecule |
| Description | An anionic surface-active agent used for its wetting properties in industry and used in medicine as an irritant and sclerosing agent for hemorrhoids and varicose veins. |
| Structure |
|
| Categories (*) | |
| Molecular Weight | 294.451 |
| Groups | approved |
| Monoisotopic Weight | 294.186480138 |
| Pharmacology | |
| Indication | For the treatment of small uncomplicated varicose veins of the lower extremities that show simple dilation with competent valves. |
| Mechanism of action | Sodium tetradecyl sulfate is a potent toxin for endothelial cells in that brief exposure to even low concentrations are effective in stripping endothelium over a considerable distance and exposing highly thrombogenic endothelium in the process. Diluted sodium tetradecyl sulfate is also able to induce a hypercoagulable state, possibly by selective inhibition of protein C, and can also promote platelet aggregation. |
| Absorption | Not Available |
| Protein binding | Not Available |
| Biotransformation | Not Available |
| Route of elimination | Not Available |
| Toxicity | LD50=1250 mg/kg (Orally in rat); LD50=3 ml/kg (Skin in rat) |
| Affected organisms |
|
| Interactions | |
| Drug Interactions | Not Available |
| Food Interactions | Not Available |
Targets
| Vitamin K-dependent protein C | |
|---|---|
| Name | Vitamin K-dependent protein C |
| Gene Name | PROC |
| Pharmacological action | yes |
| Actions | inhibitor |
| References |
|
| DTHybrid score | 0.6694 |
| Vitamin K-dependent protein S | |
| Name | Vitamin K-dependent protein S |
| Gene Name | PROS1 |
| Pharmacological action | yes |
| Actions | inhibitor |
| References |
|
| DTHybrid score | 0.6733 |