DT-Web

DB00098 - Antithymocyte globulin


Identification
Name Antithymocyte globulin
Accession Number DB00098 (BIOD00040, BTD00040)
Type biotech
Description Rabbit anti-thymocyte globulin. Thymoglobulin is a polyclonal antibody that suppresses certain types of immune cells responsible for acute organ rejection in transplant patients. Thymoglobulin is a mixture of antibodies intended to bind to various cell surface antigens. The most common mode of action of Thymoglobulin is via selective depletion of T-cells.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight Not Available
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication For prevention of renal transplant rejection
Mechanism of action Binds to multiple, T-cell specific antigens leading to T-lymphocyte cell death via complement mediated cytotoxicity or apoptosis.
Absorption Not Available
Protein binding Not Available
Biotransformation Most likely removed by opsonization via the reticuloendothelial system when bound to T lymphocytes, or by human antimurine antibody production.
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Canakinumab results in increased immunosuppressive effects; increases the risk of infection.
Rilonacept results in increased immunosuppressive effects; increases the risk of infection.
Food Interactions Not Available

Targets


T-cell surface glycoprotein CD1a
Name T-cell surface glycoprotein CD1a
Gene Name CD1A
Pharmacological action unknown
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.1737
Major histocompatibility complex class I-related gene protein
Name Major histocompatibility complex class I-related gene protein
Gene Name MR1
Pharmacological action yes
Actions antagonist
References
  • Monti P, Allavena P, Di Carlo V, Piemonti L: Effects of anti-lymphocytes and anti-thymocytes globulin on human dendritic cells. Int Immunopharmacol. 2003 Feb;3(2):189-96. - Pubmed
DTHybrid score 1.1735
Integrin alpha-L
Name Integrin alpha-L
Gene Name ITGAL
Pharmacological action yes
Actions Not Available
References
  • Monti P, Allavena P, Di Carlo V, Piemonti L: Effects of anti-lymphocytes and anti-thymocytes globulin on human dendritic cells. Int Immunopharmacol. 2003 Feb;3(2):189-96. - Pubmed
DTHybrid score 1.9851
T-lymphocyte activation antigen CD86
Name T-lymphocyte activation antigen CD86
Gene Name CD86
Pharmacological action yes
Actions Not Available
References
  • Monti P, Allavena P, Di Carlo V, Piemonti L: Effects of anti-lymphocytes and anti-thymocytes globulin on human dendritic cells. Int Immunopharmacol. 2003 Feb;3(2):189-96. - Pubmed
DTHybrid score 1.593
Low affinity immunoglobulin gamma Fc region receptor II-b
Name Low affinity immunoglobulin gamma Fc region receptor II-b
Gene Name FCGR2B
Pharmacological action yes
Actions Not Available
References
  • Monti P, Allavena P, Di Carlo V, Piemonti L: Effects of anti-lymphocytes and anti-thymocytes globulin on human dendritic cells. Int Immunopharmacol. 2003 Feb;3(2):189-96. - Pubmed
DTHybrid score 0.8268
T-cell surface glycoprotein CD4
Name T-cell surface glycoprotein CD4
Gene Name CD4
Pharmacological action yes
Actions Not Available
References
  • Monti P, Allavena P, Di Carlo V, Piemonti L: Effects of anti-lymphocytes and anti-thymocytes globulin on human dendritic cells. Int Immunopharmacol. 2003 Feb;3(2):189-96. - Pubmed
DTHybrid score 1.173
Integrin beta-1
Name Integrin beta-1
Gene Name ITGB1
Pharmacological action yes
Actions Not Available
References
  • Monti P, Allavena P, Di Carlo V, Piemonti L: Effects of anti-lymphocytes and anti-thymocytes globulin on human dendritic cells. Int Immunopharmacol. 2003 Feb;3(2):189-96. - Pubmed
DTHybrid score 1.1729
Integrin alpha-V
Name Integrin alpha-V
Gene Name ITGAV
Pharmacological action yes
Actions Not Available
References
  • Monti P, Allavena P, Di Carlo V, Piemonti L: Effects of anti-lymphocytes and anti-thymocytes globulin on human dendritic cells. Int Immunopharmacol. 2003 Feb;3(2):189-96. - Pubmed
DTHybrid score 1.1727
Integrin beta-3
Name Integrin beta-3
Gene Name ITGB3
Pharmacological action yes
Actions Not Available
References
  • Monti P, Allavena P, Di Carlo V, Piemonti L: Effects of anti-lymphocytes and anti-thymocytes globulin on human dendritic cells. Int Immunopharmacol. 2003 Feb;3(2):189-96. - Pubmed
DTHybrid score 1.6647

Predictions


Id Partner name Gene Name Score
944 T-lymphocyte activation antigen CD80 CD80 0.6162
488 Integrin alpha-IIb ITGA2B 0.2889
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.1961
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.19
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.1773
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.1772
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.1728
3816 Complement C1q subcomponent subunit B C1QB 0.168
3817 Complement C1q subcomponent subunit C C1QC 0.1679
3815 Complement C1q subcomponent subunit A C1QA 0.1679
3814 Complement C1r subcomponent C1R 0.166
2782 Complement C1s subcomponent C1S 0.0984
1733 Vitronectin VTN 0.0512
75 B-lymphocyte antigen CD20 MS4A1 0.0321
724 Interleukin-2 receptor alpha chain IL2RA 0.0188
717 Interleukin-2 receptor subunit beta IL2RB 0.0188
5898 Complement C3 C3 0.0169
955 Complement C5 C5 0.0169
844 Epidermal growth factor receptor EGFR 0.0146
777 Tumor necrosis factor TNF 0.0142
93 CAMPATH-1 antigen CD52 0.0141
757 Fusion glycoprotein F0 F 0.0141
4875 Fusion glycoprotein F0 F 0.0141
744 Myeloid cell surface antigen CD33 CD33 0.0129
793 T-cell surface antigen CD2 CD2 0.0123
6044 Serum paraoxonase/lactonase 3 PON3 0.0114
1783 Intercellular adhesion molecule 1 ICAM1 0.0112
647 Integrin alpha-4 ITGA4 0.0112
5901 T-cell surface glycoprotein CD3 zeta chain CD247 0.0104
5899 T-cell surface glycoprotein CD3 delta chain CD3D 0.0103
5900 T-cell surface glycoprotein CD3 gamma chain CD3G 0.0103
302 T-cell surface glycoprotein CD3 epsilon chain CD3E 0.0103
1269 Tumor necrosis factor receptor superfamily member 1B TNFRSF1B 0.0103
1789 Lymphotoxin-alpha LTA 0.0103
4122 Histone deacetylase 2 HDAC2 0.0099
183 Vascular endothelial growth factor A VEGFA 0.0089
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0087
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0087
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.008
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0074
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0069
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0067
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0061
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.006
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0057
3811 Cytochrome P450 19A1 CYP19A1 0.0052
6107 Cytochrome P450 3A7 CYP3A7 0.0051
4118 Cytochrome P450 3A5 CYP3A5 0.0048
4924 Cytochrome P450 2C8 CYP2C8 0.0048
6016 Cytochrome P450 2C19 CYP2C19 0.0046
1588 Multidrug resistance protein 1 ABCB1 0.0044
290 Prostaglandin G/H synthase 2 PTGS2 0.0044
4757 Cytochrome P450 2C9 CYP2C9 0.0044
4119 Cytochrome P450 2D6 CYP2D6 0.0043
4512 Cytochrome P450 3A4 CYP3A4 0.0039
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