DT-Web

DB00094 - Urofollitropin


Identification
Name Urofollitropin
Accession Number DB00094 (BIOD00104, BTD00104)
Type biotech
Description Human follicle stimulating hormone (FSH) preparation of recombinant DNA origin, which consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 980.1620
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication For treatment of female infertility
Mechanism of action FSH binds to the follicle stimulating hormone receptor which is a G-coupled transmembrane receptor. Binding of the FSH to its receptor seems to induce phosphorylation and activation of the PI3K (Phosphatidylinositol-3-kinase) and Akt signaling pathway, which is known to regulate many other metabolic and related survival/maturation functions in cells.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Follicle-stimulating hormone receptor
Name Follicle-stimulating hormone receptor
Gene Name FSHR
Pharmacological action yes
Actions agonist
References
  • Layman LC: Mutations in the follicle-stimulating hormone-beta (FSH beta) and FSH receptor genes in mice and humans. Semin Reprod Med. 2000;18(1):5-10. - Pubmed
  • Leng N, Dattatreyamurty B, Reichert LE Jr: Identification of amino acid residues 300-315 of the rat FSH receptor as a hormone binding domain: evidence for its interaction with specific regions of FSH beta-subunit. Biochem Biophys Res Commun. 1995 May 16;210(2):392-9. - Pubmed
  • Santa Coloma TA, Dattatreyamurty B, Reichert LE Jr: A synthetic peptide corresponding to human FSH beta-subunit 33-53 binds to FSH receptor, stimulates basal estradiol biosynthesis, and is a partial antagonist of FSH. Biochemistry. 1990 Feb 6;29(5):1194-200. - Pubmed
  • Dattatreyamurty B, Reichert LE Jr: Identification of regions of the follitropin (FSH) beta-subunit that interact with the N-terminus region (residues 9-30) of the FSH receptor. Mol Cell Endocrinol. 1993 May;93(1):39-46. - Pubmed
  • Lindau-Shepard B, Roth KE, Dias JA: Identification of amino acids in the C-terminal region of human follicle-stimulating hormone (FSH) beta-subunit involved in binding to human FSH receptor. Endocrinology. 1994 Sep;135(3):1235-40. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.2444

Predictions


Id Partner name Gene Name Score
148 Lutropin-choriogonadotropic hormone receptor LHCGR 0.3263
4165 P2Y purinoceptor 2 P2RY2 0.0522
2654 Complement control protein C3L 0.0419
814 Ryanodine receptor 1 RYR1 0.0397
5455 Arylsulfatase A ARSA 0.0388
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0378
2981 Phospholipase A2, membrane associated PLA2G2A 0.0305
723 Cytosolic phospholipase A2 PLA2G4A 0.0303
54 Prothrombin F2 0.0207
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