DT-Web

DB00093 - Felypressin


Identification
Name Felypressin
Accession Number DB00093 (BIOD00114, BTD00114)
Type biotech
Description Synthetic analog of lypressin with more vasoconstrictor than antidiuretic action. It is used as a hemostatic.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 1040.2190
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication For use as an alternative to adrenaline as a localising agent, provided that local ischaemia is not essential.
Mechanism of action Felypressin binds to the vasopressin receptor V1a. This causes contraction of the smooth muscle in the vascular bed, especially capillaries, small arterioles and venules.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Vasopressin V1a receptor
Name Vasopressin V1a receptor
Gene Name AVPR1A
Pharmacological action yes
Actions agonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Manning M, Stoev S, Chini B, Durroux T, Mouillac B, Guillon G: Peptide and non-peptide agonists and antagonists for the vasopressin and oxytocin V1a, V1b, V2 and OT receptors: research tools and potential therapeutic agents. Prog Brain Res. 2008;170:473-512. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.7353

Predictions


Id Partner name Gene Name Score
322 Vasopressin V2 receptor AVPR2 0.366
850 Vasopressin V1b receptor AVPR1B 0.2393
4512 Cytochrome P450 3A4 CYP3A4 0.052
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0327
290 Prostaglandin G/H synthase 2 PTGS2 0.0271
20 Prostaglandin G/H synthase 1 PTGS1 0.0254
1588 Multidrug resistance protein 1 ABCB1 0.0253
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