DT-Web

DB00092 - Alefacept


Identification
Name Alefacept
Accession Number DB00092 (BIOD00055, BTD00055)
Type biotech
Description Immunosuppressive dimeric fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgG1. Produced by CHO cells, mW is 91.4 kD.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 51801.1000
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication As an immunosuppressive drug, Alefacept can be used for treatment of moderate to severe chronic plaque psoriasis
Mechanism of action Inhibits T-lymphocyte activation and production by binding to the CD2 lymphocyte antigen.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Canakinumab Increases immunosuppressive effects and risk of infection.
Rilonacept results in increased immunosuppressive effects; increases the risk of infection.
Food Interactions Not Available

Targets


T-cell surface antigen CD2
Name T-cell surface antigen CD2
Gene Name CD2
Pharmacological action yes
Actions inhibitor
References
  • Chamian F, Lin SL, Lee E, Kikuchi T, Gilleaudeau P, Sullivan-Whalen M, Cardinale I, Khatcherian A, Novitskaya I, Wittkowski KM, Krueger JG, Lowes MA: Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis. J Transl Med. 2007 Jun 7;5:27. - Pubmed
  • da Silva AJ, Brickelmaier M, Majeau GR, Li Z, Su L, Hsu YM, Hochman PS: Alefacept, an immunomodulatory recombinant LFA-3/IgG1 fusion protein, induces CD16 signaling and CD2/CD16-dependent apoptosis of CD2(+) cells. J Immunol. 2002 May 1;168(9):4462-71. - Pubmed
  • Larsen R, Ryder LP, Svejgaard A, Gniadecki R: Changes in circulating lymphocyte subpopulations following administration of the leucocyte function-associated antigen-3 (LFA-3)/IgG1 fusion protein alefacept. Clin Exp Immunol. 2007 Jul;149(1):23-30. Epub 2007 Apr 2. - Pubmed
  • Goedkoop AY, de Rie MA, Picavet DI, Kraan MC, Dinant HJ, van Kuijk AW, Tak PP, Bos JD, Teunissen MB: Alefacept therapy reduces the effector T-cell population in lesional psoriatic epidermis. Arch Dermatol Res. 2004 Apr;295(11):465-73. Epub 2004 Feb 14. - Pubmed
  • Ortonne JP: Clinical response to alefacept: results of a phase 3 study of intramuscular administration of alefacept in patients with chronic plaque psoriasis. J Eur Acad Dermatol Venereol. 2003 Jul;17 Suppl 2:12-6. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.2363
Complement C1r subcomponent
Name Complement C1r subcomponent
Gene Name C1R
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.4125
Complement C1q subcomponent subunit A
Name Complement C1q subcomponent subunit A
Gene Name C1QA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.4208
Complement C1q subcomponent subunit B
Name Complement C1q subcomponent subunit B
Gene Name C1QB
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.4217
Complement C1q subcomponent subunit C
Name Complement C1q subcomponent subunit C
Gene Name C1QC
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.4217
Low affinity immunoglobulin gamma Fc region receptor III-A
Name Low affinity immunoglobulin gamma Fc region receptor III-A
Gene Name FCGR3A
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • da Silva AJ, Brickelmaier M, Majeau GR, Li Z, Su L, Hsu YM, Hochman PS: Alefacept, an immunomodulatory recombinant LFA-3/IgG1 fusion protein, induces CD16 signaling and CD2/CD16-dependent apoptosis of CD2(+) cells. J Immunol. 2002 May 1;168(9):4462-71. - Pubmed
  • Vaishnaw AK, TenHoor CN: Pharmacokinetics, biologic activity, and tolerability of alefacept by intravenous and intramuscular administration. J Pharmacokinet Pharmacodyn. 2002 Dec;29(5-6):415-26. - Pubmed
DTHybrid score 1.496
High affinity immunoglobulin gamma Fc receptor I
Name High affinity immunoglobulin gamma Fc receptor I
Gene Name FCGR1A
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.5847
Low affinity immunoglobulin gamma Fc region receptor II-a
Name Low affinity immunoglobulin gamma Fc region receptor II-a
Gene Name FCGR2A
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.5047
Low affinity immunoglobulin gamma Fc region receptor II-b
Name Low affinity immunoglobulin gamma Fc region receptor II-b
Gene Name FCGR2B
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.5009
Low affinity immunoglobulin gamma Fc region receptor II-c
Name Low affinity immunoglobulin gamma Fc region receptor II-c
Gene Name FCGR2C
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.5103
Low affinity immunoglobulin gamma Fc region receptor III-B
Name Low affinity immunoglobulin gamma Fc region receptor III-B
Gene Name FCGR3B
Pharmacological action unknown
Actions Not Available
References
  • da Silva AJ, Brickelmaier M, Majeau GR, Li Z, Su L, Hsu YM, Hochman PS: Alefacept, an immunomodulatory recombinant LFA-3/IgG1 fusion protein, induces CD16 signaling and CD2/CD16-dependent apoptosis of CD2(+) cells. J Immunol. 2002 May 1;168(9):4462-71. - Pubmed
DTHybrid score 1.4964

Predictions


Id Partner name Gene Name Score
2782 Complement C1s subcomponent C1S 0.7705
75 B-lymphocyte antigen CD20 MS4A1 0.3345
724 Interleukin-2 receptor alpha chain IL2RA 0.1966
717 Interleukin-2 receptor subunit beta IL2RB 0.1965
844 Epidermal growth factor receptor EGFR 0.1518
93 CAMPATH-1 antigen CD52 0.1474
777 Tumor necrosis factor TNF 0.1474
757 Fusion glycoprotein F0 F 0.147
4875 Fusion glycoprotein F0 F 0.147
744 Myeloid cell surface antigen CD33 CD33 0.1349
1783 Intercellular adhesion molecule 1 ICAM1 0.1174
647 Integrin alpha-4 ITGA4 0.1173
1733 Vitronectin VTN 0.1155
572 Integrin alpha-L ITGAL 0.1081
5901 T-cell surface glycoprotein CD3 zeta chain CD247 0.108
1789 Lymphotoxin-alpha LTA 0.108
302 T-cell surface glycoprotein CD3 epsilon chain CD3E 0.108
5900 T-cell surface glycoprotein CD3 gamma chain CD3G 0.108
5899 T-cell surface glycoprotein CD3 delta chain CD3D 0.108
1269 Tumor necrosis factor receptor superfamily member 1B TNFRSF1B 0.1079
955 Complement C5 C5 0.1033
5898 Complement C3 C3 0.103
2039 Integrin beta-3 ITGB3 0.1005
488 Integrin alpha-IIb ITGA2B 0.1004
183 Vascular endothelial growth factor A VEGFA 0.0927
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0836
554 Low-density lipoprotein receptor LDLR 0.0793
3811 Cytochrome P450 19A1 CYP19A1 0.0545
290 Prostaglandin G/H synthase 2 PTGS2 0.0457
4878 Glycoprotein hormones alpha chain CGA 0.0173
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0173
4877 Beta-mannanase man 0.0173
4869 Major capsid protein A430L 0.0173
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0173
4850 Beta-2-glycoprotein 1 APOH 0.0173
1072 Granzyme B GZMB 0.0173
4189 Alpha-galactosidase A GLA 0.0173
4889 Ig epsilon chain C region IGHE 0.0173
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0173
4880 Membrane cofactor protein CD46 0.0173
1354 Beta-glucuronidase GUSB 0.0173
442 Envelope glycoprotein gp41 0.0173
4859 Envelope glycoprotein env 0.0173
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0173
4856 CD209 antigen CD209 0.0173
4721 Beta-1,4-mannanase manA 0.0173
4852 Reticulon-4 receptor RTN4R 0.0173
4845 ADAM 33 ADAM33 0.0173
3352 Structural polyprotein Not Available 0.0173
3628 Structural polyprotein Not Available 0.0173
4892 Structural polyprotein Not Available 0.0173
660 T-cell surface glycoprotein CD1a CD1A 0.0172
6063 Major histocompatibility complex class I-related gene protein MR1 0.0172
5955 T-cell surface glycoprotein CD4 CD4 0.0172
6065 Integrin beta-1 ITGB1 0.0172
6066 Integrin alpha-V ITGAV 0.0172
1184 Interferon beta IFNB1 0.015
6858 Inactive carboxylesterase 4 CES1P1 0.015
4890 Hemagglutinin HA 0.015
6566 Hemagglutinin Not Available 0.015
1379 Interleukin-12 subunit beta IL12B 0.015
4861 Interleukin-6 receptor alpha chain IL6R 0.015
4857 Zinc-alpha-2-glycoprotein AZGP1 0.015
4193 Atrial natriuretic peptide clearance receptor NPR3 0.015
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.015
3837 Cytokine receptor common beta chain CSF2RB 0.015
3444 Cyanovirin-N Not Available 0.0139
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0139
852 Heparin cofactor 2 SERPIND1 0.0139
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0139
1859 Prostatic acid phosphatase ACPP 0.0139
3140 Hemagglutinin-neuraminidase HN 0.0139
3609 Hemagglutinin-neuraminidase HN 0.0139
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0139
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0138
2297 Genome polyprotein Not Available 0.0138
2322 Genome polyprotein Not Available 0.0138
2694 Genome polyprotein Not Available 0.0138
2719 Genome polyprotein Not Available 0.0138
2860 Genome polyprotein Not Available 0.0138
2928 Genome polyprotein Not Available 0.0138
3160 Genome polyprotein Not Available 0.0138
3260 Genome polyprotein Not Available 0.0138
4783 Genome polyprotein Not Available 0.0138
5726 Genome polyprotein Not Available 0.0138
5779 Genome polyprotein Not Available 0.0138
5867 Genome polyprotein Not Available 0.0138
6253 Genome polyprotein Not Available 0.0138
6301 Genome polyprotein Not Available 0.0138
6380 Genome polyprotein Not Available 0.0138
6381 Genome polyprotein Not Available 0.0138
6437 Genome polyprotein Not Available 0.0138
6520 Genome polyprotein Not Available 0.0138
6521 Genome polyprotein Not Available 0.0138
6652 Genome polyprotein Not Available 0.0138
6734 Genome polyprotein Not Available 0.0138
6735 Genome polyprotein Not Available 0.0138
6736 Genome polyprotein Not Available 0.0138
6737 Genome polyprotein Not Available 0.0138
6738 Genome polyprotein Not Available 0.0138
6739 Genome polyprotein Not Available 0.0138
6744 Genome polyprotein Not Available 0.0138
6748 Genome polyprotein Not Available 0.0138
6894 Genome polyprotein Not Available 0.0138
6898 Genome polyprotein Not Available 0.0138
942 T-lymphocyte activation antigen CD86 CD86 0.0138
4666 Fucose-binding lectin PA-IIL lecB 0.0131
2372 Bifunctional tail protein 9 0.0131
4787 Envelope glycoprotein gp160 env 0.0131
4820 Envelope glycoprotein gp160 env 0.0131
5727 Envelope glycoprotein gp160 env 0.0131
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0125
3480 Mannan endo-1,4-beta-mannosidase manA 0.0121
64 Neuraminidase NA 0.0121
641 Neuraminidase NA 0.0121
2676 Neuraminidase NA 0.0121
3026 Neuraminidase NA 0.0121
3519 Neuraminidase NA 0.0121
6007 Neuraminidase NA 0.0121
595 Fibrinogen alpha chain FGA 0.0121
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0117
1439 Lactotransferrin LTF 0.0117
1243 Cathepsin D CTSD 0.0114
2430 Chondroitinase B cslB 0.0111
958 Insulin-like growth factor 1 receptor IGF1R 0.0111
309 Antithrombin-III SERPINC1 0.0109
6307 Ig gamma-2 chain C region IGHG2 0.0109
2581 Chondroitinase AC cslA 0.0109
6847 Lactase-phlorizin hydrolase LCT 0.0109
6500 Phospholipase A2 PLA2G1B 0.0105
2207 Rhodopsin RHO 0.0102
4785 Ig gamma-1 chain C region IGHG1 0.0091
4604 Liver carboxylesterase 1 CES1 0.0091
76 Nitric-oxide synthase, brain NOS1 0.009
952 Dipeptidyl peptidase 4 DPP4 0.0078
3923 Cholinesterase BCHE 0.0075
20 Prostaglandin G/H synthase 1 PTGS1 0.0068
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