Identification | |||||
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Name | Pancrelipase | ||||
Accession Number | DB00085 (BIOD00067, BTD00067) | ||||
Type | biotech | ||||
Description | Pancrelipase is an enzyme mixture isolated from porcine or bovine pancreas, sometimes called pancreatin. It contains 3 enzymes: amylase, lipase, and a protease (chymotrypsin). Pancrelipase is marketed under several brand names such as Ultresa(TM) and Viokace(TM). | ||||
Structure |
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Categories (*) | |||||
Molecular Weight | 131125.6000 | ||||
Groups | approved | ||||
Monoisotopic Weight | Not Available | ||||
Pharmacology | |||||
Indication | For treatment of exocrine pancreatic insufficiency in cystic fibrosis (Ultresa(TM)), chronic pancreatitis (Viokace(TM) in combination with a proton pump inhibitor), and pancreatectomy (Viokace(TM) in combination with a proton pump inhibitor). | ||||
Mechanism of action | The lipase, protease and amylase components of pancrelipase break down fat, protein, and starches, respectively, in the small intestine. Lipase hydrolyzes fats into glycerol and fatty acids. Protease converts proteins into proteoses and derived substances, while amylase converts starches into dextrins and sugars. | ||||
Absorption | Pancrelipase is not significantly absorbed from the gastrointestinal tract. | ||||
Protein binding | Pancrelipase acts locally, so there is minimal plasma protein binding. | ||||
Biotransformation | Pancrelipase acts locally, so there is minimal metabolism. | ||||
Route of elimination | Pancrelipase is eliminated in the feces. | ||||
Toxicity | Overdose symptoms may include diarrhea or stomach upset. The most common adverse reactions seen are ear, neck, and abdominal pain; headache, nasal congestion, and beta-hemolytic streptococcal infection. | ||||
Affected organisms |
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Interactions | |||||
Drug Interactions |
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Food Interactions |
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Dietary fat | |
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Name | Dietary fat |
Gene Name | Not Available |
Pharmacological action | yes |
Actions | cleavage |
References |
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DTHybrid score | Not Available |
Dietary protein | |
Name | Dietary protein |
Gene Name | Not Available |
Pharmacological action | yes |
Actions | cleavage |
References |
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DTHybrid score | Not Available |
Dietary starch | |
Name | Dietary starch |
Gene Name | Not Available |
Pharmacological action | yes |
Actions | cleavage |
References |
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DTHybrid score | Not Available |
Id | Partner name | Gene Name | Score |
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