DT-Web

DB00076 - Digoxin Immune Fab


Identification
Name Digoxin Immune Fab
Accession Number DB00076 (BIOD00027, BIOD00046, BTD00027, BTD00046)
Type biotech
Description Digoxin Immune Fab is a sheep antibody (26-10) FAB fragment from sheep immunized with the digoxin derivative Digoxindicarboxymethylamine. It is used as an antidote for overdose of digoxin.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 47301.7000
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication For treatment of digitoxin overdose or digitalis glycoside toxicity.
Mechanism of action Binds excess digoxin or digitoxin molecules circulating in the blood.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Cumulative urinary excretion of digoxin was comparable for both products and exceeded 40% of the administered dose by 24 hours.
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Cinitapride Cinitapride can alter the absorption of digoxin as it simulates gastric emptying.
Food Interactions Not Available

Targets


Digoxin
Name Digoxin
Gene Name Not Available
Pharmacological action yes
Actions other/unknown
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • McMillin GA, Owen WE, Lambert TL, De BK, Frank EL, Bach PR, Annesley TM, Roberts WL: Comparable effects of DIGIBIND and DigiFab in thirteen digoxin immunoassays. Clin Chem. 2002 Sep;48(9):1580-4. - Pubmed
  • Chhatre S, Thillaivinayagalingam P, Francis R, Titchener-Hooker NJ, Newcombe AR, Keshavarz-Moore E: Decision-support software for the industrial-scale chromatographic purification of antibodies. Biotechnol Prog. 2007 Jul-Aug;23(4):888-94. Epub 2007 Jul 13. - Pubmed
  • Thillaivinayagalingam P, Newcombe AR, O'donovan K, Francis R, Keshavarz-Moore E: Detection and quantification of affinity ligand leaching and specific antibody fragment concentration within chromatographic fractions using surface plasmon resonance. Biotechnol Appl Biochem. 2007 May 22;. - Pubmed
  • Betten DP, Vohra RB, Cook MD, Matteucci MJ, Clark RF: Antidote use in the critically ill poisoned patient. J Intensive Care Med. 2006 Sep-Oct;21(5):255-77. - Pubmed
DTHybrid score Not Available

Predictions


Id Partner name Gene Name Score
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