DB00058 - Alpha-1-proteinase inhibitor
| Identification | |
|---|---|
| Name | Alpha-1-proteinase inhibitor |
| Accession Number | DB00058 (BIOD00002, BTD00002) |
| Type | biotech |
| Description | Human alpha-1 proteinase inhibitor or alpha-1-antitrypsin, prepared from human plasma via Cohn alcohol fractionation followed by PEG and zinc chloride fractionation. |
| Structure |
|
| Categories (*) | |
| Molecular Weight | 44324.5000 |
| Groups | approved |
| Monoisotopic Weight | Not Available |
| Pharmacology | |
| Indication | For treatment of panacinar emphysema |
| Mechanism of action | Alpha-1 proteinase inhibitor is a serine protease inhibitor (Serpin). Its primary mechanism is inhibiting the action of the serine protease called elastase (also plasmin and thrombin) in the lungs. The reactive center loop (RCL) of alpha-1 proteinase inhibitor extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable. |
| Absorption | Not Available |
| Protein binding | Not Available |
| Biotransformation | Not Available |
| Route of elimination | Not Available |
| Toxicity | Not Available |
| Affected organisms |
|
| Interactions | |
| Drug Interactions | Not Available |
| Food Interactions | Not Available |
Targets
| Leukocyte elastase | |
|---|---|
| Name | Leukocyte elastase |
| Gene Name | ELANE |
| Pharmacological action | yes |
| Actions | inhibitor |
| References |
|
| DTHybrid score | 1.2 |
Predictions
| Id | Partner name | Gene Name | Score |
|---|---|---|---|
| 870 | Granulocyte colony-stimulating factor receptor | CSF3R | 0.409 |
| 6260 | Chymotrypsin-like elastase family member 1 | CELA1 | 0.2672 |