DB00045 - OspA lipoprotein
| Identification | |
|---|---|
| Name | OspA lipoprotein |
| Accession Number | DB00045 (BIOD00054, BTD00054) |
| Type | biotech |
| Description | Vaccine against Lyme disease that contains lipoprotein OspA, an outer surface protein of Borrelia burgdorferi sensu stricto ZS7, as expressed by Escherichia coli. Lipoprotein OspA is a single polypeptide chain of 257 amino acids with lipids covalently bonded to the N terminus. It is conjugated with alum (aluminum hydroxide) as an adjuvant. |
| Structure |
|
| Categories (*) | |
| Molecular Weight | 27743.1000 |
| Groups | approved |
| Monoisotopic Weight | Not Available |
| Pharmacology | |
| Indication | For prophylactic treatment of Lyme Disease |
| Mechanism of action | OspA lipoprotein, an outer surface protein of the bacteria Borrelia burgdorferi sensu stricto ZS7, is used to stimulate the production of specific antibodies against B. burgdorferi. It is used as a vaccination against Lyme Disease, a disease carried by ticks. |
| Absorption | Not Available |
| Protein binding | Not Available |
| Biotransformation | Not Available |
| Route of elimination | Not Available |
| Toxicity | Not Available |
| Affected organisms |
|
| Interactions | |
| Drug Interactions | Not Available |
| Food Interactions | Not Available |
Targets
| Toll-like receptor 2 | |
|---|---|
| Name | Toll-like receptor 2 |
| Gene Name | TLR2 |
| Pharmacological action | yes |
| Actions | other/unknown |
| References |
|
| DTHybrid score | 1.125 |
Predictions
| Id | Partner name | Gene Name | Score |
|---|---|---|---|
| 2939 | Peptide methionine sulfoxide reductase msrA | msrA | 0.1223 |
| 2888 | DNA-repair protein XRCC4 | XRCC4 | 0.1222 |
| 2906 | Coatomer subunit gamma | COPG | 0.1222 |
| 2433 | Capsid protein P40 | UL80 | 0.0981 |
| 3569 | Capsid protein P40 | BVRF2 | 0.0981 |
| 2297 | Genome polyprotein | Not Available | 0.0828 |
| 2322 | Genome polyprotein | Not Available | 0.0828 |
| 2694 | Genome polyprotein | Not Available | 0.0828 |
| 2719 | Genome polyprotein | Not Available | 0.0828 |
| 2860 | Genome polyprotein | Not Available | 0.0828 |
| 2928 | Genome polyprotein | Not Available | 0.0828 |
| 3160 | Genome polyprotein | Not Available | 0.0828 |
| 3260 | Genome polyprotein | Not Available | 0.0828 |
| 4783 | Genome polyprotein | Not Available | 0.0828 |
| 5726 | Genome polyprotein | Not Available | 0.0828 |
| 5779 | Genome polyprotein | Not Available | 0.0828 |
| 5867 | Genome polyprotein | Not Available | 0.0828 |
| 6253 | Genome polyprotein | Not Available | 0.0828 |
| 6301 | Genome polyprotein | Not Available | 0.0828 |
| 6380 | Genome polyprotein | Not Available | 0.0828 |
| 6381 | Genome polyprotein | Not Available | 0.0828 |
| 6437 | Genome polyprotein | Not Available | 0.0828 |
| 6520 | Genome polyprotein | Not Available | 0.0828 |
| 6521 | Genome polyprotein | Not Available | 0.0828 |
| 6652 | Genome polyprotein | Not Available | 0.0828 |
| 6734 | Genome polyprotein | Not Available | 0.0828 |
| 6735 | Genome polyprotein | Not Available | 0.0828 |
| 6736 | Genome polyprotein | Not Available | 0.0828 |
| 6737 | Genome polyprotein | Not Available | 0.0828 |
| 6738 | Genome polyprotein | Not Available | 0.0828 |
| 6739 | Genome polyprotein | Not Available | 0.0828 |
| 6744 | Genome polyprotein | Not Available | 0.0828 |
| 6748 | Genome polyprotein | Not Available | 0.0828 |
| 6894 | Genome polyprotein | Not Available | 0.0828 |
| 6898 | Genome polyprotein | Not Available | 0.0828 |
| 864 | Gag-Pol polyprotein | gag-pol | 0.0787 |
| 2237 | Gag-Pol polyprotein | gag-pol | 0.0787 |
| 2326 | Gag-Pol polyprotein | gag-pol | 0.0787 |
| 2451 | Gag-Pol polyprotein | gag-pol | 0.0787 |
| 2901 | Gag-Pol polyprotein | gag-pol | 0.0787 |
| 3165 | Gag-Pol polyprotein | gag-pol | 0.0787 |
| 3722 | Gag-Pol polyprotein | gag-pol | 0.0787 |
| 6306 | Gag-Pol polyprotein | gag-pol | 0.0787 |
| 6624 | Gag-Pol polyprotein | gag-pol | 0.0787 |
| 291 | Nitric-oxide synthase, endothelial | NOS3 | 0.0566 |