DT-Web

DB00044 - Lutropin alfa


Identification
Name Lutropin alfa
Accession Number DB00044 (BIOD00056, BTD00056)
Type biotech
Description Recombinant human luteinizing hormone produced in yeast with 2 subunits, alpha = 92 residues, beta = 121 residues
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 23390.3000
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication For treatment of female infertility
Mechanism of action Binds to the luteinizing hormone receptor which then activates adenylate cylcase through G protein mediation. Adenylate cyclase then activates many other pathways leading to steroid hormone production and other follicle maturation processes.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Total body clearance is approximately 2 to 3 L/h with less than 5 percent of the dose being excreted unchanged renally.
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Lutropin-choriogonadotropic hormone receptor
Name Lutropin-choriogonadotropic hormone receptor
Gene Name LHCGR
Pharmacological action yes
Actions agonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Gibreel A, Bhattacharya S: Recombinant follitropin alfa/lutropin alfa in fertility treatment. Biologics. 2010 Feb 4;4:5-17. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.1013

Predictions


Id Partner name Gene Name Score
226 Gonadotropin-releasing hormone receptor GNRHR 0.3353
430 Follicle-stimulating hormone receptor FSHR 0.2925
3811 Cytochrome P450 19A1 CYP19A1 0.0561
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