DT-Web

DB00043 - Omalizumab


Identification
Name Omalizumab
Accession Number DB00043 (BIOD00081, BTD00081)
Type biotech
Description A recombinant DNA-derived humanized IgG1k monoclonal antibody that selectively binds to human immunoglobulin E (IgE). Xolair is produced by a Chinese hamster ovary cell suspension culture in a nutrient medium containing the antibiotic gentamicin.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 145058.2000
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication For treatment of asthma caused by allergies
Mechanism of action Xolair binds to IgE (a class of antibodies normally secreted in allergic responses), which prevents their binding to mast cells and basophils.
Absorption Not Available
Protein binding Not Available
Biotransformation Most likely removed by opsonization via the reticuloendothelial system.
Route of elimination Liver elimination of IgG includes degradation in the liver reticuloendothelial system (RES) and endothelial cells. Intact IgG is also excreted in bile.
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


High affinity immunoglobulin epsilon receptor subunit alpha
Name High affinity immunoglobulin epsilon receptor subunit alpha
Gene Name FCER1A
Pharmacological action yes
Actions Not Available
References
  • Beck LA, Marcotte GV, MacGlashan D, Togias A, Saini S: Omalizumab-induced reductions in mast cell Fce psilon RI expression and function. J Allergy Clin Immunol. 2004 Sep;114(3):527-30. - Pubmed
  • Mirkina I, Schweighoffer T, Kricek F: Inhibition of human cord blood-derived mast cell responses by anti-Fc epsilon RI mAb 15/1 versus anti-IgE Omalizumab. Immunol Lett. 2007 Apr 15;109(2):120-8. Epub 2007 Mar 1. - Pubmed
DTHybrid score 1.361
High affinity immunoglobulin epsilon receptor subunit beta
Name High affinity immunoglobulin epsilon receptor subunit beta
Gene Name MS4A2
Pharmacological action yes
Actions antagonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • DuBuske LM: IgE, allergic diseases, and omalizumab. Curr Pharm Des. 2006;12(30):3929-44. - Pubmed
DTHybrid score 1.354

Predictions


Id Partner name Gene Name Score
55 High affinity immunoglobulin epsilon receptor gamma-subunit FCER1G 0.3542
4878 Glycoprotein hormones alpha chain CGA 0.0107
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0107
1072 Granzyme B GZMB 0.0107
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0107
4850 Beta-2-glycoprotein 1 APOH 0.0107
4880 Membrane cofactor protein CD46 0.0107
4856 CD209 antigen CD209 0.0107
442 Envelope glycoprotein gp41 0.0107
4859 Envelope glycoprotein env 0.0107
4889 Ig epsilon chain C region IGHE 0.0107
4189 Alpha-galactosidase A GLA 0.0107
4869 Major capsid protein A430L 0.0107
4877 Beta-mannanase man 0.0107
757 Fusion glycoprotein F0 F 0.0107
4875 Fusion glycoprotein F0 F 0.0107
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0107
1354 Beta-glucuronidase GUSB 0.0107
4845 ADAM 33 ADAM33 0.0107
4852 Reticulon-4 receptor RTN4R 0.0107
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0107
4721 Beta-1,4-mannanase manA 0.0107
3352 Structural polyprotein Not Available 0.0107
3628 Structural polyprotein Not Available 0.0107
4892 Structural polyprotein Not Available 0.0107
4861 Interleukin-6 receptor alpha chain IL6R 0.0093
793 T-cell surface antigen CD2 CD2 0.0093
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0093
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0093
3837 Cytokine receptor common beta chain CSF2RB 0.0093
1379 Interleukin-12 subunit beta IL12B 0.0088
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0088
4890 Hemagglutinin HA 0.0088
6566 Hemagglutinin Not Available 0.0088
6858 Inactive carboxylesterase 4 CES1P1 0.0087
554 Low-density lipoprotein receptor LDLR 0.0087
1184 Interferon beta IFNB1 0.0087
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0082
852 Heparin cofactor 2 SERPIND1 0.0082
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0082
2297 Genome polyprotein Not Available 0.0082
2322 Genome polyprotein Not Available 0.0082
2694 Genome polyprotein Not Available 0.0082
2719 Genome polyprotein Not Available 0.0082
2860 Genome polyprotein Not Available 0.0082
2928 Genome polyprotein Not Available 0.0082
3160 Genome polyprotein Not Available 0.0082
3260 Genome polyprotein Not Available 0.0082
4783 Genome polyprotein Not Available 0.0082
5726 Genome polyprotein Not Available 0.0082
5779 Genome polyprotein Not Available 0.0082
5867 Genome polyprotein Not Available 0.0082
6253 Genome polyprotein Not Available 0.0082
6301 Genome polyprotein Not Available 0.0082
6380 Genome polyprotein Not Available 0.0082
6381 Genome polyprotein Not Available 0.0082
6437 Genome polyprotein Not Available 0.0082
6520 Genome polyprotein Not Available 0.0082
6521 Genome polyprotein Not Available 0.0082
6652 Genome polyprotein Not Available 0.0082
6734 Genome polyprotein Not Available 0.0082
6735 Genome polyprotein Not Available 0.0082
6736 Genome polyprotein Not Available 0.0082
6737 Genome polyprotein Not Available 0.0082
6738 Genome polyprotein Not Available 0.0082
6739 Genome polyprotein Not Available 0.0082
6744 Genome polyprotein Not Available 0.0082
6748 Genome polyprotein Not Available 0.0082
6894 Genome polyprotein Not Available 0.0082
6898 Genome polyprotein Not Available 0.0082
1859 Prostatic acid phosphatase ACPP 0.0079
3140 Hemagglutinin-neuraminidase HN 0.0079
3609 Hemagglutinin-neuraminidase HN 0.0079
3444 Cyanovirin-N Not Available 0.0079
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0079
4787 Envelope glycoprotein gp160 env 0.0076
4820 Envelope glycoprotein gp160 env 0.0076
5727 Envelope glycoprotein gp160 env 0.0076
4666 Fucose-binding lectin PA-IIL lecB 0.0073
595 Fibrinogen alpha chain FGA 0.0073
2372 Bifunctional tail protein 9 0.0073
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.007
3480 Mannan endo-1,4-beta-mannosidase manA 0.0068
64 Neuraminidase NA 0.0067
641 Neuraminidase NA 0.0067
2676 Neuraminidase NA 0.0067
3026 Neuraminidase NA 0.0067
3519 Neuraminidase NA 0.0067
6007 Neuraminidase NA 0.0067
958 Insulin-like growth factor 1 receptor IGF1R 0.0066
1243 Cathepsin D CTSD 0.0065
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0065
1439 Lactotransferrin LTF 0.0065
309 Antithrombin-III SERPINC1 0.0063
2430 Chondroitinase B cslB 0.0061
6307 Ig gamma-2 chain C region IGHG2 0.006
2581 Chondroitinase AC cslA 0.006
6847 Lactase-phlorizin hydrolase LCT 0.006
3814 Complement C1r subcomponent C1R 0.0059
6500 Phospholipase A2 PLA2G1B 0.0058
2207 Rhodopsin RHO 0.0056
4785 Ig gamma-1 chain C region IGHG1 0.005
76 Nitric-oxide synthase, brain NOS1 0.0049
4604 Liver carboxylesterase 1 CES1 0.0049
952 Dipeptidyl peptidase 4 DPP4 0.0043
3923 Cholinesterase BCHE 0.0041
20 Prostaglandin G/H synthase 1 PTGS1 0.0037
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