DT-Web

DB00032 - Menotropins


Identification
Name Menotropins
Accession Number DB00032 (BIOD00018, BTD00018)
Type biotech
Description Mixture of luteinizing hormone and follicle stimulating hormone extracted from the urine of postmeonopausal women. Composed of LH with 2 subunits, alpha = 92 residues, beta = 121 residues and FSH with 2 subunits, alpha = 92 residues, beta=111 residues
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 23390.3000
Groups approved
Monoisotopic Weight Not Available
Pharmacology
Indication For the treatment of female infertility
Mechanism of action Being a combination drug, Menotropins bind to the Follicle stimulating hormone receptor (which results in ovulation in the absence of sufficient endogenous Luteinizing hormone)and It also binds to the LH receptor, thereby stimulating proper hormone release. The drug contains both FSH and LH,therefore, it induces ovarian follicular growth and development as well as gonadal steroid production in women who do not have ovarian failure.FSH is the primary driver of follicular recruitment and growth in early folliculogenesis, while LH is important for ovarian steroidogenesis and is involved in the physiological events leading to development of a competent pre-ovulatory follicle
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Follicle-stimulating hormone receptor
Name Follicle-stimulating hormone receptor
Gene Name FSHR
Pharmacological action yes
Actions binder
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • van de Weijer BH, Mulders JW, Bos ES, Verhaert PD, van den Hooven HW: Compositional analyses of a human menopausal gonadotrophin preparation extracted from urine (menotropin). Identification of some of its major impurities. Reprod Biomed Online. 2003 Nov;7(5):547-57. - Pubmed
  • Olive DL: The role of gonadotropins in ovulation induction. Am J Obstet Gynecol. 1995 Feb;172(2 Pt 2):759-65. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.5369
Lutropin-choriogonadotropic hormone receptor
Name Lutropin-choriogonadotropic hormone receptor
Gene Name LHCGR
Pharmacological action yes
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • van de Weijer BH, Mulders JW, Bos ES, Verhaert PD, van den Hooven HW: Compositional analyses of a human menopausal gonadotrophin preparation extracted from urine (menotropin). Identification of some of its major impurities. Reprod Biomed Online. 2003 Nov;7(5):547-57. - Pubmed
  • Olive DL: The role of gonadotropins in ovulation induction. Am J Obstet Gynecol. 1995 Feb;172(2 Pt 2):759-65. - Pubmed
DTHybrid score 1.4276

Predictions


Id Partner name Gene Name Score
226 Gonadotropin-releasing hormone receptor GNRHR 0.3353
3811 Cytochrome P450 19A1 CYP19A1 0.0561
4165 P2Y purinoceptor 2 P2RY2 0.0522
2654 Complement control protein C3L 0.0419
814 Ryanodine receptor 1 RYR1 0.0397
5455 Arylsulfatase A ARSA 0.0388
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0378
2981 Phospholipase A2, membrane associated PLA2G2A 0.0305
723 Cytosolic phospholipase A2 PLA2G4A 0.0303
54 Prothrombin F2 0.0207
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