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Peptide deformylase 2


Partner ID 6377
Name Peptide deformylase 2
Synonyms 5006
Gene name def2
General function Translation, ribosomal structure and biogenesis
Specific function Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
Gene sequence + ...

TTGGAAAATATCTCTGATTTATGGAATAGTGCCTTAAAAGAATTAGAAAAAAAGGTAAGCAAGCCTAGTTATGAGACATGGTTAAAATCCACAACGGCTCATAACTTGAAGAAAGACGTATTAACGATTACAGCTCCGAATGAATTTGCTCGTGACTGGCTAGAATCTCATTACTCCGAACTAATTTCAGAAACACTATACGATTTAACAGGGGCAAAATTAGCAATTCGCTTTATTATTCCCCAAAGTCAAGCTGAAGAGGACATTGATCTGCCTCCAGTTAAGCCGAATCCAGCACAAGATGATTCAGCTCATTTACCACAGAGCATGTTAAATCCAAAATATACATTCGATACATTTGTTATTGGCTCTGGTAACCGTTTTGCCCATGCAGCTTCATTAGCTGTAGCTGAGGCGCCAGCTAAAGCGTATAATCCACTCTTTATTTACGGGGGAGTTGGACTTGGAAAGACACATTTAATGCACGCAATTGGTCATTATGTAATTGAACATAATCCAAATGCAAAAGTTGTATATTTATCATCAGAAAAATTTACAAATGAATTTATTAACTCTATTCGTGATAATAAAGCTGTTGATTTTCGTAATAAATATCGTAACGTAGATGTTTTATTGATAGATGATATTCAATTTCTTGCTGGAAAAGAACAGACTCAAGAAGAGTTTTTCCATACATTTAACGCATTACACGAAGAAAGTAAACAAATTGTAATTTCTAGTGACCGACCACCAAAAGAAATTCCAACTTTAGAAGATCGTCTTCGTTCCCGCTTTGAATGGGGACTTATTACAGACATTACGCCGCCAGATTTAGAGACACGAATTGCGATTTTACGCAAAAAAGCAAAAGCTGAAGGGCTTGATATACCAAATGAAGTTATGCTTTATATCGCAAATCAAATTGATTCAAATATTCGTGAATTAGAAGGTGCACTTATCCGAGTTGTAGCTTATTCATCTTTAATTAATAAAGATATTAATGCTGATTTAGCAGCTGAAGCACTTAAAGATATTATTCCAAATTCTAAGCCGAAAATTATCTCTATTTATGATATTCAAAAAGCTGTCGGGGACGTTTATCAAGTGAAATTAGAAGATTTTAAAGCGAAAAAACGTACAAAATCAGTTGCGTTTCCTCGCCAAATTGCAATGTATTTATCGCGCGAGCTTACAGATTCCTCTTTACCAAAAATAGGTGAAGAATTTGGTGGACGTGATCATACAACAGTTATCCATGCCCATGAAAAAATCTCTAAACTACTAAAAACCGATACGCAATTACAAAAGCAAGTTGAAGAAATTAATGGTATTTTAAAGTAG
Protein sequence + ...

MLTMKDVIREGDPILRNVAEEVSLPASEEDTTTLKEMIEFVINSQDPEMAEKYSLRPGIGLAAPQIGVSKKMIAVHVTDADGTLYSHALFNPKIISHSVERTYLQGGEGCLSVDREVPGYVPRYTRITVKATSINGEEVKLRLKGLPAIVFQHEIDHLNGVMFYDHINKENPFAAPDDSKPLER
GO Classification
function
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
binding
peptide deformylase activity
catalytic activity
ion binding
cation binding
transition metal ion binding
iron ion binding
hydrolase activity
process
macromolecule metabolism
macromolecule biosynthesis
protein biosynthesis
physiological process
metabolism
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB04310 2-[(Formyl-Hydroxy-Amino)-Methyl]-Heptanoic Acid [1-(2-Hydroxymethyl-Pyrrolidine-1-Carbonyl)-2-Methyl-Propyl]-Amide

Associated as Prediction

Id Name
DB01769 Double Oxidized Cysteine
DB01942 Formic Acid
DB02036 2-(3,4-Dihydro-3-Oxo-2h-Benzo[B][1,4]Thiazin-2-Yl)-N-Hydroxyacetamide
DB02153 3-Sulfinoalanine
DB02276 (S)-2-(Phosphonoxy)Caproyl-L-Leucyl-P-Nitroanilide
DB02810 N-(2-Acetamido)Iminodiacetic Acid
DB04310 2-[(Formyl-Hydroxy-Amino)-Methyl]-Heptanoic Acid [1-(2-Hydroxymethyl-Pyrrolidine-1-Carbonyl)-2-Methyl-Propyl]-Amide
DB04368 Bb-3497
DB08523 [HYDROXY(3-PHENYLPROPYL)AMINO]METHANOL
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