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Candidapepsin-2


Partner ID 3180
Name Candidapepsin-2
Synonyms 5219
Gene name SAP2
General function Involved in aspartic-type endopeptidase activity
Specific function Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16- Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin
Gene sequence + ...

ATGTTTTTAAAGAATATTTTCATTGCTCTTGCTATTGCTTTATTAGTCGATGCTACTCCAACAACAACCAAAAGATCAGCTGGTTTCGTTGCTTTAGATTTCAGTGTTGTGAAAACTCCTAAAGCATTCCCAGTTACTAATGGTCAAGAAGGTAAAACTTCCAAAAGACAAGCTGTCCCAGTGACTTTACACAATGAACAAGTCACTTATGCTGCTGATATTACCGTTGGATCCAATAATCAAAAACTTAATGTTATTGTTGATACTGGATCATCTGATTTATGGGTTCCTGATGTTAATGTTGATTGTCAAGTCACTTATAGTGATCAAACTGCAGATTTCTGTAAACAAAAGGGGACATATGATCCAAGTGGTTCATCAGCTTCACAAGATTTGAATACTCCATTCAAAATTGGTTATGGTGATGGATCTTCATCTCAAGGTACTTTATATAAGGATACCGTTGGATTTGGTGGTGTTTCGATTAAAAATCAAGTTTTAGCTGATGTTGATTCTACTTCAATTGATCAAGGTATTTTAGGAGTTGGTTATAAAACCAATGAAGCCGGTGGTAGTTATGATAATGTCCCTGTCACTTTAAAAAAACAAGGAGTCATTGCTAAGAATGCTTATTCACTTTATCTTAATTCTCCAGATGCTGCCACGGGACAAATAATTTTCGGTGGGGTTGATAATGCTAAATATAGTGGTTCATTAATTGCATTACCAGTTACTTCTGATCGTGAATTAAGAATTAGTTTGGGTTCAGTTGAAGTTTCTGGTAAAACCATCAATACTGATAATGTCGATGTTCTTTTGGATTCAGGTACCACCATTACTTATTTGCAACAAGATCTTGCTGATCAAATCATTAAAGCTTTCAATGGTAAATTAACTCAAGATTCCAATGGTAATTCATTCTATGAAGTTGATTGTAATTTGTCAGGGGATGTTGTATTCAATTTTAGTAAAAATGCTAAAATTTCCGTTCCAGCTTCCGAATTTGCTGCTTCTTTACAAGGTGATGATGGTCAACCATATGATAAATGTCAATTACTTTTCGATGTTAATGATGCTAACATTCTTGGTGATAACTTTTTGAGATCAGCTTATATTGTTTATGATTTGGATGATAATGAAATTTCTTTGGCTCAAGTCAAATATACTTCTGCTTCCAGTATTTCTGCCTTGACCTAA
Protein sequence + ...

MFLKNIFIALAIALLVDATPTTTKRSAGFVALDFSVVKTPKAFPVTNGQEGKTSKRQAVPVTLHNEQVTYAADITVGSNNQKLNVIVDTGSSDLWVPDVNVDCQVTYSDQTADFCKQKGTYDPSGSSASQDLNTPFKIGYGDGSSSQGTLYKDTVGFGGVSIKNQVLADVDSTSIDQGILGVGYKTNEAGGSYDNVPVTLKKQGVIAKNAYSLYLNSPDAATGQIIFGGVDNAKYSGSLIALPVTSDRELRISLGSVEVSGKTINTDNVDVLLDSGTTITYLQQDLADQIIKAFNGKLTQDSNGNSFYEVDCNLSGDVVFNFSKNAKISVPASEFAASLQGDDGQPYDKCQLLFDVNDANILGDNFLRSAYIVYDLDDNEISLAQVKYTSASSISALT
GO Classification
function
endopeptidase activity
pepsin A activity
aspartic-type endopeptidase activity
catalytic activity
hydrolase activity
peptidase activity
process
proteolysis
physiological process
metabolism
macromolecule metabolism
protein metabolism
cellular protein metabolism
See more information at   →   www.drugbank.ca

Drugs


Associated as Target

Id Name
DB03090 Ethylaminobenzylmethylcarbonyl Group
DB03241 1-Amino-1-Carbonyl Pentane
DB03659 Butylamine
DB04387 1-Hydroxy-2-Amino-3-Cyclohexylpropane
DB04451 4-Methylpiperazin-1-Yl Carbonyl Group

Associated as Prediction

Id Name
DB00212 Remikiren
DB01258 Aliskiren
DB01844 Dimethylformamide
DB02296 1-Hydroxy-3-Methylbutane
DB02803 3-Phenyl-1,2-Propandiol
DB02869 3-Amino-5-Phenylpentane
DB03024 2-Methyl-3-(2-Aminothiazolo)Propanal
DB03090 Ethylaminobenzylmethylcarbonyl Group
DB03241 1-Amino-1-Carbonyl Pentane
DB03395 Enalkiren
DB03659 Butylamine
DB03736 2-Cyclopropylmethylenepropanal
DB03968 1-Methyl-2-Oxy-5,5-Dimethyl Pyrrolidine
DB04379 N-Methyl-N-(Methylbenzyl)Formamide
DB04387 1-Hydroxy-2-Amino-3-Cyclohexylpropane
DB04451 4-Methylpiperazin-1-Yl Carbonyl Group
DB06899 N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOTHIAZIN-4-YL]ETHYL}ACETAMIDE
DB06967 6-ETHYL-5-[9-(3-METHOXYPROPYL)-9H-CARBAZOL-2-YL]PYRIMIDINE-2,4-DIAMINE
DB07059 N-{2-[6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2,2-DIMETHYL-3-OXO-2,3-DIHYDRO-4H-1,4-BENZOXAZIN-4-YL]ETHYL}ACETAMIDE
DB07113 (2S)-6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-2-(3,5-DIFLUOROPHENYL)-4-(3-METHOXYPROPYL)-2H-1,4-BENZOXAZIN-3(4H)-ONE
DB07174 6-(2,4-DIAMINO-6-ETHYLPYRIMIDIN-5-YL)-4-(3-METHOXYPROPYL)-2,2-DIMETHYL-2H-1,4-BENZOXAZIN-3(4H)-ONE
DB07244 5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE
DB08099 6-ETHYL-5-[(2S)-1-(3-METHOXYPROPYL)-2-PHENYL-1,2,3,4-TETRAHYDROQUINOLIN-7-YL]PYRIMIDINE-2,4-DIAMINE
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