Sub-Pathway Extractor and Enricher
In the era of network medicine, pathway perturbation analysis methods play a central role in the prediction of phenotype from high throughput experiments. SPECifIC is a network-based systems biology tool capable of extracting disease-perturbed subpathways within pathway networks in connection with expression data.
Our system extends pathways with missing regulatory elements, such as microRNAs, and their interactions with genes. The framework enables the extraction, visualization, and analysis of statistically significant disease-specific subpathways computed on a meta-pathway.